From July 3, it will no longer be possible to see a GP at the Urgent Care Service between 8am and 6.30pm on weekdays.
At these times, people will need to make appointments with their GP practice. A spokesperson for Isle of Wight NHS said GP practices are putting in measures to make this easier.
There will be a primary care service between 6.30pm and 8am weekdays and at weekends and bank holidays, but only for urgent cases.
An NHS spokesperson said: "Everyone is encouraged to call NHS 111 before visiting St Mary's Hospital, so that Islanders can be directed to the appropriate service.
"The Clinical Commissioning Group has considered the impact closing the walk-in centre could have on the workload of GP surgeries, NHS 111 calls, and the emergency department, and is confident that the change will work.
"On average, the in hours GP element of the urgent care service sees 18 patients a day, a very low number when compared with the 3,000 people seen by GPs in their practice each day.
"The Emergency Department at St Mary's Hospital is unaffected by these changes and remains open for serious life threatening issues."
Dr Michele Legg, a GP from Ryde and the chair of Isle of Wight Clinical Commissioning Group, said: "This is part of our arrangements to focus more resources on primary care and GP practices so that patients can receive greater support in the community, closer to their homes.
"This means small numbers will not receive their treatment at St Mary's on weekdays but instead will need to access services at their local surgery where they are a registered patient."
Changes to walk-in services at St Mary's Hospital
CHANGES to the Urgent Care Service at St Mary's Hospital, formerly known as the Beacon Centre, come into effect on Monday.
As previously reported by the County Press, the GP element of the Urgent Care Service, will be moving to an out-of-hours only service.
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