Also confirmed for the September festival is Chicago house star Derrick Carter, current number one UK singles chart holder Route94 and Bestival party favourites Horse Meat Disco.
Skream, also known as Oliver Jones, said: "I’m extremely proud, excited, over the moon to be able to say 'I'm hosting a tent at Bestival this year!’
"I’ve been playing at Bestival for the last four or five years, I think, and to be able to say 'I took Skreamizm there’, I'll die a happy man!"
Fans will not have to wait until September to get a piece of the action however, as Bestival brings the new Skreamizm line up to Mixmag's Lab this Friday, March 14.
The live stream, from 4.30pm to 6.30pm, will feature sets from Skream, Derrick Carter and Bestival chief Rob da Bank.
Visit www.mixmag.net to stream the set.