Pink will guest star on the Sunday of next year's IW Festival.
HIP-HOP star Jay-Z and American garage rockers The Strokes are the first headliners named for this year's Isle of Wight Festival.
Blondie, Pink, Orbital and Squeeze have also been unveiled days before tickets go on sale for the 2010 event.
Seaclose Park will again host the three-day extravaganza, from June 11 to 13.
Jay-Z, who released his 11th studio album The Blueprint 3 this year and overtook Elvis Presley’s record of number 1 albums in the Billboard 200, will headline the now traditional Friday dance party with The Strokes topping the bill on Saturday, with Blondie guest starring on the same night.
The Strokes have just picked up the 'NME Album of the Decade Award’ for their 2001 debut album 'Is This It’ .
The Big Top will host Squeeze, the new-wave act remembered for hits like Cool for Cats and Up The Junction on Thursday night, as a pre-festival treat for campers, and Orbital will bring their renowned live show to the tent on Saturday.
Pink, described by festival promoter John Giddings as one of the best live acts he has seen, will be a special guest on the main stage on Sunday.
Mr Giddings said: "Ever since I heard the first Strokes album, I've wanted them for the Isle of Wight. Jay-Z and Pink are two of the best live acts I have ever seen and the Blondie hits speak for themselves. I can't wait!"
Tickets go on sale on Friday (December 4) and are priced this year at £150 for adult camping and £130 for non-camping. Child tickets are £75 (camping) and £65 (non-camping). They will be available from Ticket Zone, Red Funnel and Wightlink websites.